Lukáš Tenora Selected Research

Diazooxonorleucine

11/2019	Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.
1/2019	JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.
1/2017	N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.
9/2016	Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma.

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Lukáš Tenora Research Topics

Disease

5	Neoplasms (Cancer) 01/2021 - 10/2019
2	Mental Disorders (Mental Disorder) 10/2019 - 10/2017
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2020
1	Sarcoma (Soft Tissue Sarcoma) 01/2020
1	Neurofibrosarcoma (MPNST) 01/2020
1	Lymphoma (Lymphomas) 11/2019
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2019
1	Anhedonia 01/2019
1	Neuralgia (Stump Neuralgia) 01/2017
1	Neurocognitive Disorders (Clerambault Syndrome) 01/2017
1	Glioblastoma (Glioblastoma Multiforme) 09/2016

Drug/Important Bio-Agent (IBA)

7	ProdrugsIBA 01/2021 - 09/2016
6	Glutamine (L-Glutamine)FDA Link 01/2021 - 09/2016
4	DiazooxonorleucineIBA 11/2019 - 09/2016
3	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)IBA 10/2019 - 01/2017
2	purineIBA 01/2021 - 01/2020
1	phosphoribosyl-N-formylglycineamideIBA 01/2021
1	JHU395IBA 01/2020
1	CarbonIBA 01/2020
1	IsotopesIBA 01/2020
1	KynurenineIBA 01/2020
1	NitrogenIBA 01/2020
1	Lysine (L-Lysine)FDA Link 11/2019
1	Carboxylesterase (Hydrolase S)IBA 11/2019
1	AcidsIBA 10/2019
1	GlutaminaseIBA 01/2019
1	2-(phosphonomethyl)pentanedioic acidIBA 10/2017
1	Glutamic Acid (Glutamate)FDA Link 01/2017
1	alkoxyl radicalIBA 01/2017
1	EstersIBA 01/2017
1	Analgesics (Analgesic Drugs)IBA 01/2017

Therapy/Procedure

2	Therapeutics 01/2021 - 01/2017
1	Immunotherapy 01/2020